RESOURCES

CLINICAL STUDIES

THE SCIENCE BEHIND THE BENEFITS OF COLLAGEN

A great deal of research has been done into the benefits of collagen for joint health, beauty, wellness and sports recovery. Here’s just a sampling:

BEAUTY FROM WITHIN

Rosenberg SW (1957) Further studies in the use of gelatin in the treatment of brittle nails. AMA Arch Derm 76:330–335.
Tyson TL (1950). The effect of gelatin on fragile finger nails. J Invest Dermatol 14:323–325
Claim: Collagen improves nail quality and density.

Scala J, Hollies NRS, Sucher KP (1976) Effect of daily gelatin ingestion on human scalp hair. Nutr Rep Int 13:579–592.
Claim: Collagen improves hair thickness and growth.

Morganti P, Randazzo SD (1984) Nutrition and hair. J Appl Cosmetol 2:41–49.
Claim: Collagen improves hair thickness and growth.
Matsumoto H, Ohara H, Ito K, Nakamura Y, Takahashi S. Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Lett. Batter. New Technol. Med., 7, 386–390 (2006).
Claim: Marine collagen peptides improved skin condition after daily ingestion for 6 weeks.

Sumida E, Hirota A, Kuwaba K. The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood. J Nutr Food 2004;7:45-52.
Claim: 10 grams of marine collagen improved water absorption capacity in 20 Japanese women over 60 days.

Ohara H, Ito K, Lida H, Matsumoto H. Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. J Jpn Soc Food Sci Technol 2009;56:137-145.
Claim: 5g – 10g of marine collagen showed significant improvements in hydration of the stratum corneum after 4 weeks in women aged 25-45.

Béguin, Alain (12/01/2005). "A novel micronutrient supplement in skin aging: a randomized placebo‐controlled double‐blind study". Journal of cosmetic dermatology (1473-2130), 4 (4), p. 277.
Claim: Marine collagen showed visible improvement in overall skin appearance and reduction of fine lines in 3 months. Increase in dermis density.

Tanaka, M., Koyama, Y., & Nomura, Y. (2009) “Effects of Collagen Peptide Ingestion on UV-B-induced Skin Damage.” Bioscience, Biotechnology, and Biochemistry, 73:4, 930-932, DOI: 10.1271/bbb.80649.
Claim: Daily collagen peptide ingestion suppressed UV-B-induced decreases in skin hydration, hyperplasia of the epidermis, and decreases in soluble type 1 collagen. Collagen is a beneficial supplement to suppress UV-B-induced skin damage and photoaging.

Genovese, L., Corbo, A., & Sibilla, S. (2017). An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin Pharmacology and Physiology, 30(3), 146-158.
Claim: Collagen supplementation showed significant increase in skin elasticity (+7.5%) and an improvement in skin texture after daily oral consumption. Collagen may have photo-protective effects and help improve skin health.

Haratake, A. et al. (2015). “Effects of oral administration of collagen peptides on skin collagen content and its underlying mechanism using a newly developed low collagen skin mice model.” Journal of Functional Foods, 16, 174-182.
Claim: Oral collagen peptide administration had a significant effect on the collagen content in the skin of low collagen model mice by altering the state of fibroblasts (regulate the synthesis of collagen and ECM matrix).

Wang, Z., Wang, Q., Wang, L., Xu, W., He, Y., Li, Y., He, S. and Ma, H. (2017), Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice. J. Sci. Food Agric., 97: 2721–2726. doi:10.1002/jsfa.8098.
Claim: Oral ingestion (6 months) of marine collagen hydrolysates increased collagen content, antioxidant enzyme activities, and improved the appearance and structure of skin in ICR mice.
Claim: Collagen supplementation had an obvious improvement in color, luster, and quantity of hair in chronologically aged ICR mice.

ANTI-AGING

Roland W. Moskowitz. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, Volume 30, Issue 2, 2000, Pages 87-99, ISSN 0049-0172 https://doi.org/10.1053/sarh.2000.9622
Claim: Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.

Nicholas P. Hays, Helen Kim, Amanda M. Wells, Oumitana Kajkenova, William J. Evans. Effects of Whey and Fortified Collagen Hydrolysate Protein Supplements on Nitrogen Balance and Body Composition in Older Women. In Journal of the American Dietetic Association, Volume 109, Issue 6, 2009, Pages 1082-1087, ISSN 0002-8223, https://doi.org/10.1016/j.jada.2009.03.003.
Claim: Fortified hydrolyzed collagen maintained nitrogen balanced and preserved lean body mass in elderly women.

Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial. Adv Skin Wound Care. 2006;19-92-96.
Claim: Collagen hydrolysate supplementation enhances wound healing in elderly people in long-term care.

Tanaka, M., Koyama, Y., & Nomura, Y. (2009) “Effects of Collagen Peptide Ingestion on UV-B-induced Skin Damage.” Bioscience, Biotechnology, and Biochemistry, 73:4, 930-932, DOI: 10.1271/bbb.80649
Claim: Daily collagen peptide ingestion suppressed UV-B-induced decreases in skin hydration, hyperplasia of the epidermis, and decreases in soluble type 1 collagen. Collagen is a beneficial supplement to suppress UV-B-induced skin damage and photoaging.

De Luca, C., Mikhal'chik, E.,V., Suprun, M. V., Papacharalambous, M., Truhanov, A. I., & Korkina, L. G. (2016). Skin antiaging and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: A single-blind case-control clinical study. Oxidative Medicine and Cellular Longevity, doi: http://dx.doi.org.prox.lib.ncsue.edu/10.1155/2016/4389410
Claim: ??

Olsen GB, Savage S, Olson J. (2000). The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and temporomandibular joint pain. Cranio, 18(2):135-141
Claim: Daily collagen ingestion significantly decreased pain levels in chronic (2 – 15+ years) fibromyalgia and concurrent tempormandibular joint problems after supplementing for 90 days.

Zhang, H., Yang, P., Zhou, C., Li, S., & Hong, P. (2017). Marine collagen peptides from the skin of nile tilapia (oreochromis niloticus): Characterization and wound healing evaluation. Marine Drugs, 15(4), 102.
Claim: Marine collagen peptides enhance the process of wound healing in rabbits.

Subhan, F., Kang, H. Y., Lim, Y., Ikram, M., Baek, S.-Y., Jin, S., … Yoon, S. (2017). Fish Scale Collagen Peptides Protect against CoCl2/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells. Oxidative Medicine and Cellular Longevity, 2017, 9703609. http://doi.org/10.1155/2017/9703609
Claim: Marine collagen peptides demonstrate beneficial effects on inflammatory or immune-mediated skin diseases.

BONE & JOINT HEALTH

Numerous scientific studies point to the benefits of collagen for joints and bones.

Guillerminet F, et al. (2010). Hydrolyzed collagen improved bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 46(3):827-834.
Claim: Collagen supplementation showed higher growth and differentiation on osteoblasts and osteoclasts in rats during 12 week study. Osteoprotective action.

Jackix EA, Cúneo F, Amaya-Farfan J, Assunção JV, Quintaes KD. A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. J Med Food 2010;13(6):1-6.
Claim: Collagen supplementation showed greater conservation of bone composition and strength in rats.

Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin 2008;24(5):1485-96.
Claim: Collagen consumption (10g/day) demonstrated significant improvement in joint pain and protection of cartilage in 147 athletes.

Takeda S, Jong-Hoon P, Kawashima E, Ezawa I, Omi N. Hydrolyzed collagen intake increases bone mass of growing rats trained with running exercise. J Int Soc Sports Nutr. 2013;10(35).
Claim: Collagen supplementation promotes bone mass in rats.

Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food (2011);14(6):618-24.
Claim: Collagen supplements are involved in cartilage matrix synthesis, anti-hypertensive and cardioprotective activity, and anti-oxidant activity.

Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin 2006;22(11):2221-32.
Claim: Hydrolyzed collagen oral supplementation may accumulate in the cartilage and stimulate significant increases in the synthesis of ECM (extracellular matrix) macromolecules by chondrocytes.

Bruyère O, Zegels B, Leonori I, Rabenda V, Janssen A, Bourges C, Reginster JY. Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study. Complement Ther Med 2012;20(3):124-30.
Claim: Collagen supplementation with 200 patients (50+ years old) showed significant improvement in safety and efficacy after 6 months (1,200 mg/day).

Porfino E, Fanaro GB. Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: a systematic review. Nutricao Clinica. 2014:153-164.
Claim: Collagen has a positive therapeutic role in osteoporosis/osteoarthritis. CH may increase bone mineral density, protect articular cartilage, and provide symptomatic pain relief. Dosage ranges from 8 – 12g/day.

SPORTS RECOVERY

Zhang, H., Yang, P., Zhou, C., Li, S., & Hong, P. (2017). Marine collagen peptides from the skin of nile tilapia (oreochromis niloticus): Characterization and wound healing evaluation. Marine Drugs, 15(4), 102.
Claim: Marine collagen peptides enhance the process of wound healing in rabbits.

Nicholas P. Hays, Helen Kim, Amanda M. Wells, Oumitana Kajkenova, William J. Evans. Effects of Whey and Fortified Collagen Hydrolysate Protein Supplements on Nitrogen Balance and Body Composition in Older Women. In Journal of the American Dietetic Association, Volume 109, Issue 6, 2009, Pages 1082-1087, ISSN 0002-8223, https://doi.org/10.1016/j.jada.2009.03.003.
Claim: Fortified hydrolyzed collagen maintained nitrogen balanced and preserved lean body mass in elderly women.

Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial. Adv Skin Wound Care. 2006;19-92-96.
Claim: Collagen hydrolysate supplementation enhances wound healing in elderly people in long-term care.

Jackix EA, Cúneo F, Amaya-Farfan J, Assunção JV, Quintaes KD. A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. J Med Food 2010;13(6):1-6.
Claim: Collagen supplementation showed greater conservation of bone composition and strength in rats.

Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin 2008;24(5):1485-96.
Claim: Collagen consumption (10g/day) demonstrated significant improvement in joint pain and protection of cartilage in 147 athletes.

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